Manchester United will renew acquaintances with former striker Ruud van Nistelrooy, who is currently caretaker manager of Leicester City. The Red Devils, who progressed to this stage following a dramatic penalty shootout victory over Arsenal, will be looking to exploit Leicester's precarious league position.
Tottenham Hotspur have been drawn away to Aston Villa. While Spurs emerged victorious in their Premier League meeting earlier in the season, they have since been hit by a spate of injuries. Villa, too, have been inconsistent of late.
Chelsea will travel to the south coast to face Brighton & Hove Albion. The Blues have a strong recent record against the Seagulls, but Brighton have significantly strengthened their squad since their last meeting.
Everton, under the stewardship of recently appointed manager David Moyes, will host Bournemouth. The Cherries have impressed under Andoni Iraola, but Everton will be eager to kickstart their season.
Elsewhere, the draw has been kind to some of the Premier League's big hitters. Liverpool will face either Plymouth Argyle or a non-league side, while Manchester City could face either Leyton Orient or Derby County.
